The addition of 1% of calcium hydroxyapatite gives extra stimulation effect by activating fibroblasts to collagen stimulation. Stimulate Man is made from hyaluronic acid derived from Bacillus subtilis and it is cross-linked by PEG polymer. In addition to hyaluronic acid it contains amino acids - Glycine and L-Proline - that are main ingredients of collagen. Calcium hydroxyapatite used in Neauvia fillers has smaller particle sizes (8-12 microns) and is well spread and cross-linked in the hydrogel. This assures stability of the particles that have no possibility to migrate.